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Talk About It
Talk About It
Nicole gives US powerful ballads on her new release that will readily be embraced, but Talk About It, is also a reflection of the musical versatility of the prolific energetic artists. [Note: This product is an authorized CD-R and is manufactured on demand]
Now this is world music--the kind of sound that defies classification and stretches itself beyond musical borders. Following up her multiple Dove Award-winning debut, Nicole C. Mullen is back with a vengeance on Talk About It. The energetic release carries a warm and joyous feel that unites rather than divides through its incorporation of pop, Ramp;B, hip-hop, and gospel. This melting-pot strategy complements Mullen's lyrical dedication to racial reconciliation. For example, on the rocking and rollicking "Black Light," Mullen sings about the need for integrity in today's leaders. She can also jam hard on such numbers as the release's title track, "Witness," and "Sometimes." Mullen changes speeds well on "Baby Girl" and "Let Me Go," paying musical homage to the likes of Stevie Wonder and Sly and the Family Stone. In fact, producer (and husband) David Mullen amply uses horns throughout, giving a slight wink to '60s soul. The ultimate result is a wonderful collage of stylish influences that will please music fans on repeated listens. --Michael Lyttle
Talk About It
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
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This open-label, single-arm study investigated the long-term efficacy of tafasitamab plus lenalidomide in 81 patients with relapsed/refractory diffuse large B-cell lymphoma. The response rate was 57.5%, including complete responses in 40.0% of patients, and the median duration of response was 43.9 months. This treatment is a valuable option for patients not eligible for autologous stem-cell transplantation.
Grey zone lymphoma is a B-cell lymphoma, unclassifiable, with features intermediate between those of large B-cell lymphoma and classic Hodgkin lymphoma. The in-depth study of the two adolescent patients described in this case report expands the clinicopathological and genomic spectrum of this rare pediatric disease. Moreover, it provides information on their response to treatment.
The clinical picture of 56 patients with congenital amegakaryocytic thrombocytopenia due to MPL mutations was much more varied than previously thought. Twenty-five per cent of them had no signs of thrombocytopenia at birth, and 50% had non-hematologic defects. Pancytopenia developed in (nearly) all patients and hematopoietic stem-cell transplantation was effective in 87% of cases.
Sickle red blood cells exhibit abnormal adhesion to laminin mediated by Lu/BCAM protein at their surface. This study provides evidence of the involvement of oxidative stress in post-translational modifications of Lu/BCAM which impact the protein’s distribution and cis-interaction with glycophorin C at the cell surface activating its adhesive function in dense sickle red cells. The authors speculate that antioxidant drugs might attenuate this phenomenon.